Counts CJ, Spadaro AV, Cerbini TA, Krotulski AJ, Greller HA, Nelson LS, Ruck BE, Calello DP
Morbidity and Mortality Weekly Report (MMWR)Abstract
Tianeptine is an atypical tricyclic antidepressant with pharmacologic effects that include enhancement of serotonin reuptake and mu-opioid receptor agonism. The Food and Drug Administration has not approved tianeptine for use in the United States; however, it is readily purchased in elixir formulations online or at gas stations informally referred to as “gas station heroin” (1–3). This report describes an uncharacteristic spike in tianeptine ingestions in New Jersey during June–November 2023, with severe associated clinical effects with synthetic cannabinoid receptor agonists (SCRAs) identified in samples of the ingested products.
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