Camille Watson-Gooden, Holly G. Pierzynsk, Jianmei Liu, Marc Gregerson, Alex J. Krotulski, Donna M. Iula
Cayman Chemical - Application NotesKey Features:
The co-elution of 7-hydroxy mitragynine and mitragynine pseudoindoxyl (two important mitragynine-related alkaloids) by traditional Gas Chromatography Mass Spectrometry (GC-MS) methods makes testing a challenge for analysts.
If testing methods are unable to resolve these two substances in casework, identification and quantification can become compromised.
The rise of consumer products on the drug market containing potent semi-synthetic opioids derived from kratom, such as 7-hydroxy mitragynine and mitragynine pseudoindoxyl, is of great public health and safety concern.
Several chromatographic methods to achieve separation are explored in this application note. Method information presented herein may be used to assist labs in developing methods to identify and quantify 7-hydroxy mitragynine and mitragynine pseudoindoxyl in seized drug analysis and/or toxicology cases.
Developed in collaboration with Dr. Alex Krotulski, NPS Discovery, Center for Forensic Science Research and Education (CFSRE).
