Since 2018, NPS Discovery has reported 174 newly discovered NPS in the United States (Figure 1). NPS opioids remain the largest subclass (Figure 2). In 2024, NPS Discovery reported the discovery of 20 NPS for the first time.

Figure 1Figure 1: Newly discovered NPS reported for the first time since 2018.
Figure 2Figure 2: Breakdown by subclass of newly discovered NPS, 2018-2024.
 

Since 2018, NPS Discovery has identified 269 NPS in forensic samples (Figure 3). NPS opioids, stimulants, and cannabinoids represent the largest subclasses observed. In 2024, 103 total NPS were detected (Figure 4).

Figure 3Figure 3: Breakdown by subclass of individual NPS detected 2018-2024
Figure 4Figure 4: Individual NPS detected each year, cumulative since 2018.
 

In 2024, NPS Discovery observed more than 5,200 total NPS detections within examined sample populations (Figure 5), a portion of nearly 20,000 total NPS detections since our program launched in 2018 (Figure 6).

Figure 5 Figure 5: Total number of NPS detections by year among samples analyzed since 2018.
Figure 6Figure 6: Cumulative number of total NPS detections since 2018.
 
DOWNLOAD THE 2024 YEAR IN REVIEW