THCP

The following information was compiled in October 2025 and is subject to change as new research is conducted and as new information becomes available:

Description: THCP is a semi-synthetic cannabinoid categorized as a phytocannabinoid and is structurally similar to other phytocannabinoids (e.g., THC, CBD, CBDP). THCP is present at trace amounts in Cannabis sativa; however, drug products purportedly containing synthetically derived THCP have been sold online and in smoke shops in the form of plant materials, edibles, and vapes.^1-3 THCP was first identified by our laboratory in May 2025 and confirmed after acquiring standard reference material.

Sample Source: CHOP Pediatric Hospital of Medicine (Philadelphia, PA)

Sample Appearance: Edible/Gummy

Pharmacology: THCP is reported to have high affinity for the human CB₁ and CB₂ receptors [K_i = 1.2 nM (CB₁), 6.2 nM (CB₂)], and cannabimimetic activity higher than that of THC.¹

Toxicology: THCP has not been detected in toxicology cases to date at the CFSRE.

Drug Materials: THCP has been detected in ten drug materials to date at the CFSRE.

Demographics / Geographics: The first drug material originated from Pennsylvania and THCP was identified without the presence of other drugs.

Legal Status: The legal status of THCP is currently ambiguous and evolving in the United States.

Class:

Cannabinoid

Appearance:

Edible/Gummy

Formula:

C23H34O2

MW:

342.5

[M+]:

342

[M+H]+:

343.2632

IUPAC:

3-heptyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydrobenzo[c]chromen-1-ol

Report Date:

October 17, 2025