N-sec-Butyl Butylone

The following information was compiled in March 2026 and is subject to change as new research is conducted and as new information becomes available:

Description: N-sec-Butyl butylone is a novel stimulant characterized as a cathinone bearing structural resemblance to other synthetic cathinones (e.g., butylone, N-isopropyl butylone). There are currently no available data investigating the potency and activity of N-sec-butyl butylone; however, due to structural similarity to other synthetic cathinones, it is hypothesized that N-sec-butyl butylone acts on dopamine and serotonin (5-HT) transporters to inhibit reuptake and promote the release of neurotransmitters.¹ A structurally similar substance, N-ethyl pentylone (DAT IC₅₀=0.13±0.01 µM, SERT IC₅₀=6.37±0.09 µM), demonstrated stronger inhibitory effects on DAT/SERT compared to pentylone (DAT IC₅₀=0.21±0.02 µM, SERT IC₅₀=137.9±13.4 µM), likely due to the elongation of the alkyl amino group.^2,3 N-sec-Butyl butylone is not explicitly scheduled in the United States. N-sec-Butyl butylone was first detected at the CFSRE in a drug material from Florida, and has since been detected in one postmortem blood specimen received from Florida alongside fentanyl and cocaine.

Class:

Stimulant

Appearance:

Drug Material

Formula:

C15H21NO3

MW:

263.3

[M+]:

264

[M+H]+:

264.1567

IUPAC:

1-(benzo[d][1,3]dioxol-5-yl)-2-(sec-butylamino)butan-1-one

Report Date:

March 24, 2026