N-Pyrrolidino Metodesnitazene

The following information was compiled in June 2025 and is subject to change as new research is conducted and as new information becomes available:

Description: N-Pyrrolidino metodesnitazene is a novel synthetic opioid bearing structural resemblance to metonitazene, metodesnitazene, N-pyrrolidino metonitazene, and other nitazene analogues. N-Pyrrolidino metodesnitazene was first identified by our laboratory in October 2024 and confirmed via standard reference material.

Sample Source: Drug Overdose Toxico-Surveillance (DOTS) Reporting Program, American College of Medical Toxicology (ACMT), University of California (San Francisco, CA)

Sample Appearance: Blood specimen

Pharmacology: In vitro pharmacological data available for N-pyrrolidino metodesnitazene show that this drug is an active opioid and is approximately 100x less potent than N-pyrrolidino metonitazene (its 5-NO₂ counterpart) and 30x less potent than fentanyl.¹

Toxicology: N-Pyrrolidino metodesnitazene has been detected in one toxicology case at the CFSRE.

Drug Materials: N-Pyrrolidino metodesnitazene has not been detected in drug materials at the CFSRE.

Demographics / Geographics: The toxicology specimen originated from California and N-pyrrolidino metodesnitazene was found alongside fentanyl and stimulants (e.g., methamphetamine, cocaine).

Legal Status: N-Pyrrolidino metodesnitazene is not currently a scheduled substance in the United States.

Class:

Opioid

Appearance:

Blood

Formula:

C21H25N3O

MW:

335.4

[M+]:

335

[M+H]+:

336.2070

IUPAC:

2-[(4-methoxyphenyl)methyl]-1-(2-pyrrolidin-1-ylethyl)benzimidazole

Report Date:

June 27, 2025