N-Pyrrolidino Metodesnitazene
The following information was compiled in June 2025 and is subject to change as new research is conducted and as new information becomes available:
Description: N-Pyrrolidino metodesnitazene is a novel synthetic opioid bearing structural resemblance to metonitazene, metodesnitazene, N-pyrrolidino metonitazene, and other nitazene analogues. N-Pyrrolidino metodesnitazene was first identified by our laboratory in October 2024 and confirmed via standard reference material.
Sample Source: Drug Overdose Toxico-Surveillance (DOTS) Reporting Program, American College of Medical Toxicology (ACMT), University of California (San Francisco, CA)
Sample Appearance: Blood specimen
Pharmacology: In vitro pharmacological data available for N-pyrrolidino metodesnitazene show that this drug is an active opioid and is approximately 100x less potent than N-pyrrolidino metonitazene (its 5-NO2 counterpart) and 30x less potent than fentanyl.1
Toxicology: N-Pyrrolidino metodesnitazene has been detected in one toxicology case at the CFSRE.
Drug Materials: N-Pyrrolidino metodesnitazene has not been detected in drug materials at the CFSRE.
Demographics / Geographics: The toxicology specimen originated from California and N-pyrrolidino metodesnitazene was found alongside fentanyl and stimulants (e.g., methamphetamine, cocaine).
Legal Status: N-Pyrrolidino metodesnitazene is not currently a scheduled substance in the United States.
- Class:
- Opioid
- Appearance:
- Blood
- Formula:
- C21H25N3O
- MW:
- 335.4
- [M+]:
- 335
- [M+H]+:
- 336.2070
- IUPAC:
- 2-[(4-methoxyphenyl)methyl]-1-(2-pyrrolidin-1-ylethyl)benzimidazole
- Report Date:
- June 27, 2025
