N-Pyrrolidino Ethylene Isotonitazene

The following information was compiled in October 2025 and is subject to change as new research is conducted and as new information becomes available:

Description: N-Pyrrolidino ethylene isotonitazene is a synthetic opioid bearing structural resemblance to other nitazene analogues (e.g., N-pyrrolidino isotonitazene, isotonitazene, ethylene etonitazene). N-Pyrrolidino ethylene isotonitazene differs from currently known nitazene analogues with a lengthened linker between the benzyl and benzimidazole groups.¹ N-Pyrrolidino ethylene isotonitazene was first identified by our laboratory in March 2025 and confirmed after acquiring standard reference material.

Sample Source: Public Health & Harm Reduction Collaborators

Sample Appearance: Tan solid material, blue solid material, white solid material

Pharmacology: N-Pyrrolidino ethylene isotonitazene has not be explicitly studied; however, available data suggest that some substitutions and lengthening of the linker group may lower affinity and potency compared to their non-substituted counterparts.¹

Toxicology: N-Pyrrolidino ethylene isotonitazene has not been detected in toxicology cases to date.

Drug Materials: N-Pyrrolidino ethylene isotonitazene has been detected in eight drug materials to date.

Demographics / Geographics: The drug materials originated from California, Rhode Island, Illinois, etc. N-Pyrrolidino ethylene isotonitazene was identified without other drugs present and with traditional drugs (e.g., fentanyl, methamphetamine, ketamine) and NPS (e.g., metonitazene, clonazolam, spirochlorphine).

Legal Status: N-Pyrrolidino ethylene isotonitazene is not currently scheduled in the United States.

Class:

Opioid

Appearance:

Tan solid material

Formula:

C24H30N4O3

MW:

422.5

[M+]:

422

[M+H]+:

423.2391

IUPAC:

2-[2-(4-isopropoxyphenyl)ethyl]-5-nitro-1-(2-pyrrolidin-1-ylethyl)benzimidazole

Report Date:

October 7, 2025