N-Piperidinyl Tapentadol

The following information was compiled in February 2026 and is subject to change as new research is conducted and as new information becomes available:

Description: N-Piperidinyl tapentadol, referred to online as “PiPTapentadol” and also called “Piptap3”, is a novel opioid and bears structural similarity to tapentadol, a potent synthetic opioid analgesic. N-Piperidinyl tapentadol was first identified through online gray market sites and posts on social media forums (e.g., Reddit) as a potential alternative for other synthetic opioids (O-desmethyltramadol, tapentadol).¹ Currently, there is no information regarding the pharmacological effects of N-piperidinyl tapentadol. N-Piperidinyl tapentadol  was identified in a white powder ordered from an online vendor through the CFSRE NPS Discovery Test Purchase Program. The sample was sold as “PiPTapentadol” and subsequently confirmed as the sole component via mass spectrometry and nuclear magnetic resonance (NMR). N-Piperidinyl tapentadol is not currently scheduled in the United States.

Class:

Opioid

Appearance:

White powder

Formula:

C17H27NO

MW:

261.4

[M+]:

261

[M+H]+:

262.2165

IUPAC:

3-[1-ethyl-2-methyl-3-(1-piperidyl)propyl]phenol

Report Date:

February 4, 2026