N-Piperidinyl Methiodone

The following information was compiled in February 2026 and is subject to change as new research is conducted and as new information becomes available:

Description: N-Piperidinyl methiodone (also known as DPP-26) is a novel synthetic opioid bearing structural resemblance to other synthetic opioids (e.g., methiodone, dipyanone, methadone). Currently, no available data investigates the potency and activity of N-piperidinyl methiodone; however, due to structural similarity to studied synthetic opioids, it is hypothesized that N-piperidinyl methiodone acts as a mu-opioid receptor agonist and has the potential to induce analgesia, euphoria, and respiratory depression.^1,2 N-Piperidinyl methiodone is not currently scheduled in the United States. N-Piperidinyl methiodone was first detected at the CFSRE in a white material from New England without the presence of other drugs. Since the initial identification, N-piperidinyl methiodone has been identified at the CFSRE in one postmortem blood specimen alongside methiodone and 2oxo-PCP.

Class:

Opioid

Appearance:

White powder

Formula:

C23H31NO2S

MW:

385.6

[M+]:

385

[M+H]+:

386.2148

IUPAC:

1-(4-(ethylsulfonyl)-4,4-diphenylbutan-2-yl)piperidine

Report Date:

February 10, 2026