MMB-PICA

The following information was compiled in December 2025 and is subject to change as new research is conducted and as new information becomes available:

Description: MMB-PICA is a novel synthetic cannabinoid categorized as an indole with a substituted valine methyl ester and bears structural similarity to other indole synthetic cannabinoids (e.g., MDMB-FUBICA, ADB-BICA, MMB-FUBICA). MMB-PICA was first identified by our laboratory in July 2025 and  confirmed after acquiring standard reference material.

Sample Source: Office of the Chief Medical Examiner (Richmond, VA)

Sample Appearance: Blood specimen

Pharmacology: MMB-PICA is reported to a potent cannabinoid receptor agonist with significant binding affinity to the CB₁ (K_i=15.1 nM) and CB₂ (K_i=14.0 nM) receptors and is reported to have lower potency than its corresponding indazole.¹

Toxicology: MMB-PICA has been detected in one toxicology case to date at the CFSRE.

Drug Materials: MMB-PICA has not been detected in drug materials to date at the CFSRE.

Demographics / Geographics: The toxicology specimen originated from Virginia and MMB-PICA was identified alongside other synthetic cannabinoids (e.g., MDMB-4en-PINACA, 5F-ADB) and naloxone.

Legal Status: MMB-PICA is not currently scheduled in the United States.

Class:

Cannabinoid

Appearance:

Blood specimen

Formula:

C20H28N2O3

MW:

344.5

[M+]:

344

[M+H]+:

345.2173

IUPAC:

methyl 3-methyl-2-[(1-pentylindole-3-carbonyl)amino]butanoate

Report Date:

December 9, 2025