Methiodone

The following information was compiled in February 2026 and is subject to change as new research is conducted and as new information becomes available:

Description: Methiodone (also known as IC-26) is a novel synthetic opioid bearing structural resemblance to methadone. This drug was first synthesized by Winthrop Laboratories in the 1950s as an antitussive drug.^1,2 Effective doses of methiodone for cough suppression in humans are reported to be 2-4 mg, through it can produce morphine-like effects with single oral doses ranging from 25-70 mg.² Wolbach & Fraser hypothesized that methiodone has a potential for addiction similar to that of morphine.² Methiodone was first detected in a drug sample containing white material received from New England and has since been detected in five toxicological specimens alongside nitazene analogues and orphine analogues, primarily N-propionitrile chlorphine.

Class:

Opioid

Appearance:

White powder

Formula:

C20H27NO2S

MW:

345.5

[M+]:

345

[M+H]+:

346.1835

IUPAC:

4-(ethylsulfonyl)-N,N-dimethyl-4,4-diphenylbutan-2-amine

Report Date:

February 10, 2026