Dihydro-7-Hydroxy Mitragynine

The following information was compiled in November 2025 and is subject to change as new research is conducted and as new information becomes available:

Description: Dihydro-7-hydroxy mitragynine (“MGM-15”) is synthetic derivative of 7-hydroxy mitragynine. It is structurally similar to known kratom alkaloids and is the primary component in products being sold as “MGM-15”.¹ Analysis of dihydro-7-hydroxy mitragynine is challenging due to the analytical conversion of dihydro-7-hydroxy mitragynine to mitragynine during GC-MS analysis. Dihydro-7-hydroxy mitragynine was first identified by our laboratory in September 2025 and confirmed after acquiring standard reference material.

Sample Source: In Collaboration with StreetCheck

Sample Appearance: Tan solid material

Pharmacology: Dihydro-7-hydroxy mitragynine is reported to be a partial agonist of the mu-opioid receptor and has increased opioid receptor affinity compared to 7-hydroxy mitragynine due to stereospecific saturation of the imine N(1)-C(2) double bond.¹

Toxicology: Dihydro-7-hydroxy mitragynine has been detected in one toxicology cases at the CFSRE.

Drug Materials: Dihydro-7-hydroxy mitragynine has been detected in two drug materials at the CFSRE.

Demographics / Geographics: Drug materials originated from New England and toxicology sample originated from New Jersey. Dihydro-7-hydroxy mitragynine was identified alongside mitragynine, 7-hydroxy mitragynine, and trace ketamine.

Legal Status: Dihydro-7-hydroxy mitragynine is not currently scheduled in the United States.

Class:

Miscellaneous

Appearance:

Tan solid material

Formula:

C23H32N2O5

MW:

416.5

[M+]:

416

[M+H]+:

417.2384

IUPAC:

methyl (E)-2-(3-ethyl-7a-hydroxy-8-methoxy-2,3,4,6,7,12,12a,12b-octahydro-1H-indolo[2,3-a]quinolizin-2-yl)-3-methoxy-prop-2-enoate

Report Date:

November 11, 2025