Despentyl-UR-144

The following information was compiled in November 2025 and is subject to change as new research is conducted and as new information becomes available:

Description: Despentyl-UR-144 is a categorized as a precursor in the synthesis of synthetic cannabinoids (e.g., XLR-11 analogs, UR-144 analogs, etc.). Despentyl-UR-144 was first identified in Tokyo in 2014 alongside the synthetic cannabinoid FUB-144.¹ Despentyl-UR-144 was first identified by our laboratory in July 2025 and confirmed after acquiring standard reference material.

Sample Source: Colombo, Sri Lanka

Sample Appearance: White powder

Pharmacology: Despentyl-UR-144 is reported to have affinity for the CB₁ and CB₂ cannabinoid receptors with half-maximal effective concentrations (EC₅₀) of 2,360 nM and 27.9 nM, respectively.¹

Toxicology: Despentyl-UR-144 has not been detected in toxicology cases to date at the CFSRE.

Drug Materials: Despentyl-UR-144 has been detected in one drug material to date at the CFSRE.

Demographics / Geographics: The drug material originated from Colombo, Sri Lanka. Despentyl-UR-144 was identified alone.

Legal Status: Despentyl-UR-144 is not currently scheduled in the United States.

Class:

Cannabinoid

Appearance:

White powder

Formula:

C16H19NO

MW:

241.3

[M+]:

241

[M+H]+:

242.1539

IUPAC:

1H-indol-3-yl-(2,2,3,3-tetramethylcyclopropyl)methanone

Report Date:

November 4, 2025