AMB-4en-PINACA

The following information was compiled in December 2025 and is subject to change as new research is conducted and as new information becomes available:

Description: AMB-4en-PINACA is a novel synthetic cannabinoid that bears structural similarity to other indazole carboxamide-based synthetic cannabinoids (e.g., MDMB-4en-PINACA, ADB-4en-PINACA, 5F-MDMB-PINACA). AMB-4en-PINACA was first identified by our laboratory in November 2025 and confirmed after acquiring standard reference material.

Sample Source: NMS Labs (Willow Grove, PA)

Sample Appearance: Paper material

Pharmacology: No information is available for the activity and potency of AMB-4en-PINACA; however, based on structural similarity to MDMB-4en-PINACA and ADB-4en-PINACA, it is assumed that AMB-4en-PINACA is a full agonist with high affinity for the CB₁ receptor and at least moderate potency compared to traditional cannabinoids (e.g., THC, CBD).¹

Toxicology: AMB-4en-PINACA has not been detected in toxicology cases to date at the CFSRE.

Drug Materials: AMB-4en-PINACA has been detected in one drug material to date at the CFSRE.

Demographics / Geographics: The drug material originated from New York and AMB-4en-PINACA was identified alongside other synthetic cannabinoids (e.g., AB-CHMINACA, MDMB-4en-PINACA).

Legal Status: AMB-4en-PINACA is not currently scheduled in the United States.

Class:

Cannabinoid

Appearance:

Paper material

Formula:

C18H24N4O2

MW:

328.4

[M+]:

328

[M+H]+:

329.1972

IUPAC:

N-(1-carbamoyl-2-methyl-propyl)-1-pent-4-enyl-indazole-3-carboxamide

Report Date:

December 5, 2025