5-Chloro Desmethylchlorphine

The following information was compiled in May 2026 and is subject to change as new research is conducted and as new information becomes available:

Description: 5-Chloro desmethylchlorphine is a novel synthetic opioid with structurally similarity to other benzimidazolones (e.g., chlorphine, 5,6-dichloro desmethylchlorphine). No data currently exists regarding potency and activity of 5-chloro desmethylchlorphine; however, the dichloro analog (5,6-dichloro desmethylchlorphine) is reported to be a mu-opioid receptor agonist with similar potency to morphine.^1-3 5-Chloro desmethylchlorphine is not currently scheduled in the United States. 5-Chloro desmethylchlorphine has been identified in three drug materials originating from Massachusetts and Ohio.  5-Chloro desmethylchlorphine was found alongside other opioids (e.g., fentanyl, ortho-methylfentanyl, heroin) and xylazine.

Class:

Opioid

Appearance:

Drug Material

Formula:

C19H19Cl2N3O

MW:

376.3

[M+]:

375

[M+H]+:

376.0983

IUPAC:

5-chloro-1-(1-(4-chlorobenzyl)piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

Report Date:

June 1, 2026