4F-Alpha-PHP

The following information was compiled in June 2025 and is subject to change as new research is conducted and as new information becomes available:

Description: 4F-Alpha-PHP is a synthetic stimulant with structural similarity to other known synthetic cathinones (e.g., 4-methyl-PHP, 4F-alpha-PVP, alpha-PHP). 4F-Alpha-PHP was first identified in 2017 and has since been identified in bulk drug seizures and for sale on grey market sites.1,2 4F-Alpha-PHP was first identified by our laboratory in January 2025 and confirmed after acquiring standard reference material.

Sample Source: Florida 4th District Chief Medical Examiner’s Office (Jacksonville, FL)

Sample Appearance: Blood specimen

Pharmacology: 4F-Alpha-PHP is reported to inhibit neurotransmitter reuptake with high potency at the dopamine transporter (hDAT) and lower potency at the norepinephrine transporter (hNET).3

Toxicology: 4F-Alpha-PHP has been detected in one toxicology case to date at the CFSRE.

Drug Materials: 4F-Alpha-PHP has not been detected in drug materials to date at the CFSRE.

Demographics / Geographics: The toxicology specimen originated from Jacksonville, FL, and 4F-alpha-PHP was found alongside other synthetic cathinones (e.g., alpha-PiHpP, alpha-PiHP, MD-PiHP, and N-isopropyl butylone), traditional stimulants (e.g., cocaine and methamphetamine), and fentanyl.

Legal Status: 4F-Alpha-PHP is not currently a scheduled substance in the United States.



Class:
Stimulant
Appearance:
Blood
Formula:
C16H22FNO
MW:
263.4
[M+]:
263
[M+H]+:
264.1758
IUPAC:
1-(4-fluorophenyl)-2-pyrrolidin-1-yl-hexan-1-one
Report Date:
June 24, 2025
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