4F-Alpha-PHP
The following information was compiled in June 2025 and is subject to change as new research is conducted and as new information becomes available:
Description: 4F-Alpha-PHP is a synthetic stimulant with structural similarity to other known synthetic cathinones (e.g., 4-methyl-PHP, 4F-alpha-PVP, alpha-PHP). 4F-Alpha-PHP was first identified in 2017 and has since been identified in bulk drug seizures and for sale on grey market sites.1,2 4F-Alpha-PHP was first identified by our laboratory in January 2025 and confirmed after acquiring standard reference material.
Sample Source: Florida 4th District Chief Medical Examiner’s Office (Jacksonville, FL)
Sample Appearance: Blood specimen
Pharmacology: 4F-Alpha-PHP is reported to inhibit neurotransmitter reuptake with high potency at the dopamine transporter (hDAT) and lower potency at the norepinephrine transporter (hNET).3
Toxicology: 4F-Alpha-PHP has been detected in one toxicology case to date at the CFSRE.
Drug Materials: 4F-Alpha-PHP has not been detected in drug materials to date at the CFSRE.
Demographics / Geographics: The toxicology specimen originated from Jacksonville, FL, and 4F-alpha-PHP was found alongside other synthetic cathinones (e.g., alpha-PiHpP, alpha-PiHP, MD-PiHP, and N-isopropyl butylone), traditional stimulants (e.g., cocaine and methamphetamine), and fentanyl.
Legal Status: 4F-Alpha-PHP is not currently a scheduled substance in the United States.
- Class:
- Stimulant
- Appearance:
- Blood
- Formula:
- C16H22FNO
- MW:
- 263.4
- [M+]:
- 263
- [M+H]+:
- 264.1758
- IUPAC:
- 1-(4-fluorophenyl)-2-pyrrolidin-1-yl-hexan-1-one
- Report Date:
- June 24, 2025
