2C-I

The following information was compiled in January 2026 and is subject to change as new research is conducted and as new information becomes available:

Description:  2C-I is a novel hallucinogen characterized as a 2,5-phenethylamine and bears structural similarity to other “2C” drugs (e.g., 2C-B, 2C-E). 2C-I was first synthesized in the 1990s and has been reported in overdoses and fatalities since 2003 with highest prevalence from 2011 to 2012.^1,2 2C-I is reported to be highly selective for the serotonin (5-HT) receptors in the brain, particularly  5-HT_2A, with LD₅₀ values higher than that of other phenethylamine derivatives in animal models (LD₅₀ 2C-I: 1.368 mM, LD₅₀ 25I-NBOMe: 0.236 mM).^2,3 2C-I is a Schedule I drug in the United States. 2C-I has been detected in one drug material to date at the CFSRE and has not yet been identified in toxicology specimens. 2C-I was identified in a drug material from New England without the presence of other drugs.

Class:

Hallucinogen

Appearance:

Drug Material

Formula:

C10H14INO2

MW:

307.1

[M+]:

307

[M+H]+:

308.0142

IUPAC:

2-(4-iodo-2,5-dimethoxy-phenyl)ethanamine

Report Date:

January 15, 2026