October 15, 2025
Drug Checking Quarterly Report (Q2 2025): Mid-Atlantic, USA
Partnerships between the Center for Forensic Science Research and Education (CFSRE) and the Philadelphia Department of Public Health (PDPH) and Pennsylvania Groundhogs Group (PAG) were established to accurately assess the drug supply in the Mid-Atlantic region, epi-centered around Philadelphia, PA.

Summary and Notable Findings:

  • 332 samples were analyzed between April 1 and June 30, 2025.
  • Fentanyl adulteration is shifting—for alpha-2 agonists, in favor of medetomidine over xylazine, and with local anesthetics (e.g., lidocaine, procaine, tetracaine) increasing in prevalence.
  • Novel synthetic opioids continue to appear—nitazene analogues were infrequently detected in quarter, while fentanyl analogues (e.g., carfentanil, para-fluorofentanyl) were more common.
  • Observations of BTMPS have decreased from Q1 to Q2 2025.
  • MDMA (n=6) was observed more than NPS simulants (n=1).
  • Synthetic cannabinoids 5F-ADB (n=2) and MDMB-4en-PINACA (n=4) were detected among K2/Spice suspected samples.
  • The CFSRE is validating an expanded quantitative test panel to include more drugs and adulterants than previously quantifiable. Updated quantitative results will follow in future quarterly reports.
  • The CFSRE has implemented a customized data and information management system, which enables effective and efficient sample tracking, testing, reporting, and data analysis.
DOWNLOAD THE REPORT