7-Hydroxy Mitragynine

The following information was compiled in June 2025 and is subject to change as new research is conducted and as new information becomes available:

Description: 7-Hydroxy mitragynine is an alkaloid found at small amounts in Mitragyna speciosa (Kratom). It is also an active metabolite of the alkaloid mitragynine, the primary psychoactive component in Kratom. In late 2024, 7-hydroxy mitragynine emerged as the primary component in drug products being marketed and sold as “Kratom” or “7OHM”.^1,2 7-Hydroxy mitragynine was first identified in drug products by our laboratory in February 2025 and confirmed via standard reference material.

Sample Source: Purchased from smoke shop (Pennsylvania)

Sample Appearance: Tablets, solid orange material

Pharmacology: 7-Hydroxy mitragynine is reported to be a highly selective partial agonist of the mu-opioid receptor and is approximately 10x more potent than mitragynine.^2,3

Toxicology: 7-Hydroxy mitragynine has been detected in one toxicology case to date at the CFSRE.

Drug Materials: 7-Hydroxy mitragynine has been detected in six drug materials to date at the CFSRE.

Demographics / Geographics: The toxicology specimen originated from Michigan and drug materials originated from Pennsylvania and Illinois. 7-Hydroxy mitragynine has been identified alongside mitragynine and related alkaloids, as well as other NPS (e.g., flubromazepam, 2F-2oxo-PCE).

Legal Status: 7-Hydroxy mitragynine is not explicitly scheduled in the United States.

Class:

Miscellaneous

Appearance:

Tablets

Formula:

C23H30N2O5

MW:

414.5

[M+]:

414

[M+H]+:

415.2227

IUPAC:

methyl (E)-2-(3-ethyl-7a-hydroxy-8-methoxy-2,3,4,6,7,12b-hexahydro-1H-indolo[2,3-a]quinolizin-2-yl)-3-methoxy-prop-2-enoate

Report Date:

June 25, 2025