Research conducted at the CFSRE focuses on novel approaches to serological identification, evaluating newly released or upcoming products and methods, and improving methodology for the collection and analysis of challenging sample types. Our most current work is focused on protein mass spectrometry-based techniques for body fluid identification, in particular its application to the analysis of sexual assault kits, as well as the development of robust approaches for the genetic analysis of firearms, cartridge cases and explosives and evaluating and validating probabilistic genotyping platforms.
CFSRE researchers in the forensic biology unit work in collaboration with local laboratories, vendors, university’s, and law enforcement to evaluate new methods and technologies to optimize the recovery and/or interpretation of DNA from challenging sample types. The resulting information and resources found in this section allows for the dissemination of these optimized methods or evaluations to laboratories that are interested in implementing these suggested procedures.
The CFSRE is working in collaboration with vendors, law enforcement, and practitioner communities to fundamentally understand NGS technology, develop training materials, identify and resolve gaps for implementation into a QAS accredited DNA laboratory, and develop recommendations for high-quality workflows for forensic casework applications. The information and resources consolidated here by the CFSRE allows for the rapid dissemination of information to interested communities.
In response to the limitations of currently employed serological techniques (i.e., colorimetric, enzymatic, and antibody-based assays), several “Next Generation” technologies for improved biological fluid identification testing have emerged within the past decade. The CFSRE, working in collaboration with the University of Denver, have developed and extensively tested multiple protein mass spectrometry based workflows for high throughput human body fluid identification.