Brodifacoum in Synthetic Cannabinoids

Brodifacoum is a second generation, highly toxic pesticide commonly used for the elimination  of rodents. It was registered by the U.S. Department of Agriculture (USDA) in 1979 after Congress passed the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) in 1947. The U.S. Environmental Protection Agency (EPA) determined that certain toxic substances (including brodifacoum) needed to be reregistered and reevaluated post its initial registration in 1979. The reregistration eligibility decision for the rodenticide cluster was approved, and the risk mitigation decision in 2008 stated the second-generation anticoagulants were able to be reregistered for use in commercial pest control and not in consumer products. The EPA pesticide product label for brodifacoum from May 5, 2021, states that this pesticide can be fatal if swallowed, inhaled, or absorbed through the skin. It acts as an inhibitor for the vitamin K1 epoxide reductase enzyme in the liver, thus inhibiting the production and recycling of activated vitamin K1, which is used to make functional blood clotting factors. Brodifacoum is classified as an anticoagulant because blood clotting is inhibited.

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